Blar i forfatter "Sapkota, Dipak"

Viser treff 1-4 av 4

    • Combined loss of expression of involucrin and cytokeratin13 is associated with poor prognosis in squamous cellcarcinoma of mobile tongue. 

      Pandey, Sushma; Søland, Tine Merete; Bjerkli, Inger-Heidi; Sand, Lars Peter; Petersen, Fernanda Cristina; Costea, Daniela Elena; Senguven, Burcu; Sapkota, Dipak (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-02)
      Background - This study aimed to evaluate the prognostic significance of expression levels of involucrin (IVL), cytokeratin (CK)-10 and -13 at different intratumor sites (tumor center and invading area) of oral tongue squamous cell carcinoma (OTSCC).<p> <p>Methods - IVL, CK13 and CK10 expression levels were examined in a multicenter cohort of 146 OTSCCs using immunohistochemistry. External mRNA ...

    • High-risk human papilloma virus was not detected in a Norwegian cohort of oral squamous cell carcinoma of the mobile tongue 

      Søland, Tine Merete; Bjerkli, Inger-Heidi; Georgsen, Jeanette B; Schreurs, Olaf Joseph Franciscus; Jebsen, Peter Wilhelm; Laurvik, Helene; Sapkota, Dipak (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-03)
      <p><i>Objectives - </i>The presence of and the causative role of high‐risk human papilloma virus (HPV) is a subject of controversy in oral squamous cell carcinoma (OSCC). The disagreement can be related to the misclassification of OSCC as oropharyngeal squamous cell carcinoma and/or lack of standard detection methods. This study aimed to examine the presence of transcriptionally active high‐risk HPV ...

    • Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma 

      Pandey, Sushma; Osman, Tarig Al-Hadi; Sharma, Sunita; Vallenari, Evan Michael; Shahdafar, Aboulghassem; Pun, Chin B.; Gautam, Dej K.; Uhlin-Hansen, Lars; Rikardsen, Oddveig G; Johannessen, Anne Christine; Costea, Daniela Elena; Sapkota, Dipak (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-23)
      <i>Background</i> - We previously showed a tumor‐suppressive function of S100A14 in oral squamous cell carcinoma (OSCC). This study aimed to examine the prognostic significance and differentiation‐related function of S100A14 in OSCC.<p><p> <i>Methods</i> - S100A14 expression was examined in 170 OSCCs from Norwegian and Nepalese populations using immunohistochemistry. Pro‐differentiation function ...

    • The prognostic role of combining Krüppel-like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas 

      Søland, Tine Merete; Solhaug, Maren Bråten; Bjerkli, Inger-Heidi; Schreurs, Olaf Joseph Franciscus; Sapkota, Dipak (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-01)
      Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor involved in inflammation, cancer development, and progression. However, the relationship between KLF4, inflammation, and prognosis in oral cancer is not fully understood. KLF4 expression levels were examined in a multicenter cohort of 128 oral squamous cell carcinoma (OSCC) specimens from the tongue (OTSCC) using immunohistochemistry. ...